Title: Prediction of B-cell epitopes in Listeriolysin O, a cholesterol-dependent cytolysin secreted by Listeria monocytogenes
Authors: Jones MS, Carter JM
Journal: Adv Bioinformatics
Accepted date: 2013 Aug 8
Interpretive summary: Listeria monocytogenes, a foodborne bacterium that causes disease in humans, is responsible for approximately 1600 clinical cases annually in the United States and there is a need for a sensitive yet inexpensive test. We studied one protein required by the bacteria for producing disease, called LLO. Using computer analysis we showed that parts of LLO could be used to develop a diagnostic test for the presence of Listeria monocytogenes. This work will help public health professionals track outbreaks and reduce disease.