Title: Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus)
Authors: Leavens T, Tell L, Kissell L, Smith D, Wagner S, Shelver W, Huali W, Baynes R, Riviere J
Journal: Food Addit Contam Part A
Accepted date: 2014 Jun 18
Interpretive summary: Flunixin is a non-steroidal anti-inflammatory drug that is approved for use in cattle under restricted conditions. Cattle producers can ensure that flunixin residues do not contaminate meat or milk products by observing the proper administration route and the proper pre-harvest withdrawal period established by the US-FDA. However, the pre-harvest withdrawal period was determined by treating healthy, mature cattle with flunixin and measuring its depletion over time. In practice, flunixin is given to sick animals of all ages and production classes and the rate of drug depletion may change with animal maturity and with the health of an animal. The purpose of this study was to build a mathematical model which would simulate the depletion of flunixin from body tissues of cattle under a variety of situations. The model incorporated a large amount of data describing flunixin disposition and incorporated these data with parameters that describe physiological and biochemical processes of cattle. It is anticipated that the model could be used to predict withholding times for milk and/or meat of cattle treated with flunixin under non-traditional circumstances.
Publication date: 2014 Aug 1
Related projects: Metabolic Fate of Chemical and Biological Contaminants