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Published Articles from USDA ARS National Program 108: Food Safety
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Title: Structural characterization of product ions by electrospray ionization and quadrupole time-of-flight mass spectrometry to support regulatory analysis of veterinary drug residues in foods
Authors: Nunez A, Geis-Asteggiante L, Lehotay SJ, Lightfield AR
Journal: Rapid Commun Mass Spectrom
Accepted date: 2014 Feb 15
Interpretive summary: Veterinary drugs are frequently used in animal production, but misuse can lead to illegal residues in food. Countries have set laws to limit residue levels, which have become a major trade issue involving billions of dollars. In the USA, the USDA Food Safety and Inspection Service (FSIS) is responsible for surveillance and enforcement monitoring of veterinary drug residues in meat and poultry products. A common method for monitoring drug residues is by the use of ion fragments produced by mass spectrometry in association with high-pressure liquid chromatography. However ion fragments been monitored are usually selected due to signal intensities instead of being correctly selected on their unique structural characteristics, potentially leading to false positives. In this work modern high-resolution mass spectrometry has been used to elucidate the structure of ions for 62 veterinary drugs that are of concern and are routinely use for detection of residues in food. The use of this technology has allowed the precise determination of molecular formulas of the ion fragments permitting the elaboration of molecular structures; consequently, more effective methods can be developed for the identification of veterinary drug residues in food.
Publication date: 2014 May 30
Volume: 28
Issue: 10
Pages: 1061-81