Title: Functional roles of FgLaeA in controlling secondary metabolism, sexual development, and virulence in Fusarium graminearum
Authors: Kim H, Lee S, Jo S, Mccormick SP, Butchko R, Proctor R, Yun S
Journal: PLoS One
Accepted date: 2013 Jun 24
Interpretive summary: Trichothecenes are toxic substances produced by the wheat disease fungus Fusarium graminearum. We are interested in reducing or eliminating these toxins from wheat. In an effort to accomplish that goal, we need to understand the biology of the fungus with regard to trichothecene production. In this study, we found that in F. graminearum, the gene laeA turns on the genes that control the production of trichothecenes and other mycotoxins, the sexual and asexual development of the fungus, and its ability to cause plant disease. Knocking out this gene greatly reduced both toxin production and disease symptoms. A better understanding of this type of global control may lead to novel strategies for reducing or eliminating these toxins from wheat.
Publication date: 2013 Jul 16
Related projects: Genetic Control of Fusarium Mycotoxins to Enhance Food Safety