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Managing the Emerging Risk of Trichinellosis in Organic and Free Range Pork

1. Develop serological assays that differentiate swine chronically infected with zoonotic T. spiralis from swine only transiently exposed to T. murrelli.

2. Estimate how frequently pastured pigs and feral swine are exposed to infection with enzootic and zoonotic species of trichinella.

More Info:
Approach: Screen expression libraries of T. spiralis and T. murrelli with hyper-immune sera from swine to identify clones encoding species-specific diagnostic antigens. Develop antibodies that discriminate among the two types of infection. Test in experimentally infected swine. Apply to panels of serum collected from feral swine and pastured pigs. Validate against genotyped parasite specimens obtained from tissue samples matched with serum.
Funding Source:
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Project Number:
Rosenthal, Benjamin
Project Reports:
Published Journal Articles USDA ARS (NP 108):
Modeling effective transmission strategies and control of the world’s most successful parasite
Turner M, Lenhart S, Rosenthal BM, Sullivan A, Zhao X.
Theor Popul Biol. 2013 Jun;86:50-61.
Evidence for a population bottleneck in an Apicomplexan parasite of caribou and reindeer, Besnoitia tarandi
Madubata C, Dunams-Morel DB, Elkin B, Oksanen A, Rosenthal BM .
Infect Genet Evol. 2012 Dec;12(8):1605-13.
Eimeria that infect fish are diverse and are related to, but distinct from, those that infect terrestrial vertebrates
Molnár K, Ostoros G, Dunams-Morel D, Rosenthal BM .
Infect Genet Evol. 2012 Dec;12(8):1810-5.
Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages
Su C, Khan A, Zhou P, Majumdar D, Ajzenberg D, Dardé ML, Zhu XQ, Ajioka JW, Rosenthal BM, Dubey JP, Sibley LD .
Proc Natl Acad Sci USA. 2012 Apr 10;109(15):5844-9.
Discernible but limited introgression has occurred where Trichinella nativa and the T6 genotype occur in sympatry
Dunams-Morel DB, Reichard MV, Torretti L, Zarlenga DS, Rosenthal BM .
Infect Genet Evol. 2012 Apr;12(3):530-8.
Development of a single larva microsatellite analysis to investigate the population structure of Trichinella spiralis
La Rosa G, Marucci G, Rosenthal BM, Pozio E .
Infect Genet Evol. 2012 Mar;12(2):369-76.
Food Safety Categories:
On-Farm Food Safety
Diseases and Allergies
Farm-to-Table Categories:
On-farm food production