Food Safety Research Information Office
Title:Chemical and Biological Residues in Foods
Objective:

Objective 1: Update data on levels of dioxins and related compounds in the domestic food supply to provide Food Safety agencies with an adequate profile of the situation and confirm the safety and competitiveness of U.S. foods.

Objective 2: Develop inexpensive, rapid, sensitive assays or improved diagnostic tools to screen samples for pesticides and other environmental contaminants such as dioxins.

Objective 3: Investigate sources which contribute to levels of these contaminants in food animals, that are, feed components, dust or soils, treated wood, and identify intervention strategies that may reduce the levels.

Objective 4: Investigate the uptake, metabolism, distribution, excretion, and fate after excretion of environmental contaminants in animal systems with the goal of developing pharmacokinetic rate and volume constants pertinent to residue depletion modeling and real time calculation of withdrawal intervals to protect both food products and the environment. Subobjectives include in vivo and in vitro metabolism studies and fate and transport in the environment studies.

More Info:
Approach:
Persistent organic pollutants, e.g. dioxins, dioxin-like compounds, brominated flame retardants, and perfluorinated compounds are ubiquitous environmental contaminants that can enter the food chain as animals are exposed through their surroundings and feeds. Because these compounds can cause numerous health effects in animals including cancers, developmental and neurological problems, and immune and reproductive systems disruptions, U.S. and international health organizations recommend continuing to decrease human exposure by lowering levels in foods and the environment. Our research efforts focus on reducing exposure to these contaminants using four approaches. First, surveys of the general food supply (especially meat, poultry, and farm-raised catfish) will be conducted and will provide background levels of these compounds in U.S. foods, serve as a periodic monitor of domestic foods, and track temporal trends. These data are critical to regulatory agencies for developing risk assessments. Second, rapid, inexpensive assays will be developed for detecting contaminants in food products. If successful, these assays may result in widespread monitoring of the food supply and environment, which currently is not feasible due to the high costs or lack of analytical methods. Third, sources that contribute to livestock exposure throughout the production process will be investigated and cataloged. Once identified, these sources may be eliminated, controlled, or avoided in farming practices. Fourth, basic research to determine pharmacokinetic parameters for these pollutants in laboratory and farm animals, potential remediation methods such as bacterial degradation or composting practices, and transport in soils and into plants will be investigated through controlled laboratory studies. These data will be used to estimate animal withdrawal intervals, evaluate source attribution, and elucidate strategies to decrease contaminant levels in food animals or the environment.
Funding Source:United States Department of Agriculture (USDA), Agricultural Research Service (ARS)
Type:Appropriated
Start Date:2011
End Date:2016
Project Number:5442-32000-013-00
Accession Number:421006
Institutions:USDA/ARS - Northern Plains Area
Investigators:Hakk, Heldur
Lupton, Sara
Shelver, Weilin
Project Reports:2013 Annual Report
2012 Annual Report
2011 Annual Report
Published Journal
Articles USDA
ARS (NP 108):
Distribution and excretion of perfluorooctane Sulfonate (PFOS) in beef cattle (Bos taurus)
Lupton SJ, Huwe JK, Smith DJ, Dearfield KL, Johnston JJ .
J Agric Food Chem. 2014 Jan 20;62(5):1167–73.
Multiplex immunoassay for persistent organic pollutants in tilapia: comparison of imaging- and flow cytometry-based platforms using spectrally encoded paramagnetic microspheres
Meimaridou A, Haasnoot W, Shelver WL, Franek M, Nielen MW.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013 May 8;30(5):843-52.
Novel and distinct metabolites identified following a single oral dose of α- or γ-hexabromocyclododecane in mice
Hakk H, Szabo DT, Huwe J, Diliberto J, Birnbaum LS.
Environ Sci Technol. 2012 Dec 18;46(24):13494-503.
Dioxin congener patterns in commercial catfish from the United States and the indication of mineral clays as the potential source
Huwe JK, Archer JC.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012 Dec 13;30(2):331-8.
A highly sensitive and selective immunoassay for the detection of tetrabromobisphenol A in soil and sediment
Xu T, Wang J, Liu SZ, Lü C, Shelver WL, Li QX, Li J.
Anal Chim Acta. 2012 Nov 2;751:119-27.
Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000-2002
Wang D, Atkinson S, Hoover-Miller A, Shelver WL, Li QX.
J Hazard Mater. 2012 Jul 15;223-224:72-8.
Development of indirect competitive fluorescence immunoassay for 2,2',4,4'-tetrabromodiphenyl ether using DNA/dye conjugate as antibody multiple labels
Fan ZY, Keum YS, Li QX, Shelver WL, Guo LH.
J Environ Sci. 2012 Jul;24(7):1334-40.
Sensitive immunoassay detection of multiple environmental chemicals on protein microarrays using DNA/dye conjugate as a fluorescent label
Fan Z, Keum YS, Li QX, Shelver WL, Guo LH.
J Environ Monit. 2012 May;14(5):1345-52.
Absorption and excretion of 14C-perfluorooctanoic acid (PFOA) in Angus cattle (Bos taurus)
Lupton SJ, Huwe JK, Smith DJ, Dearfield KL, Johnston JJ.
J Agric Food Chem. 2012 Feb 1;60(4):1128-34.
Multiplex screening of persistent organic pollutants in fish using spectrally encoded microspheres
Meimaridou A, Kalachova K, Shelver WL, Franek M, Pulkrabova J, Haasnoot W, Nielen MW.
Anal Chem. 2011 Nov 15;83(22):8696-702.
Differences in tissue distribution of HBCD alpha and gamma between adult and developing mice
Szabo DT, Diliberto JJ, Huwe JK, Birnbaum LS.
Toxicol Sci. 2011 Sep;123(1):256-63.
Non-Journal Publications:
Generation of antibodies and development of environmental application of immunoassays for PBDEs - (Abstract Only)
Shelver, W.L. 2013. Generation of antibodies and development of environmental application of immunoassays for PBDEs [abstract]. The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, March 17-21, 2013, Philadelphia, PA.
Comparative metabolism of [14C]alpha-, beta-, and gamma-hexabromocyclododecane (HBCD) in rats - (Abstract Only)
Hakk, H., Huwe, J.K. 2012. Comparative metabolism of [14C]alpha-, beta-, and gamma-hexabromocyclododecane (HBCD) in rats. 244th American Chemical Society Meeting & Exposition, August 19-23, 2012, Philadelphia, PA. Abstract 26.
ADME Studies of all Three Hexabromocyclododecane (HBCD) Diastereomers in Rats - (Abstract Only)
Hakk, H., Huwe, J.K. 2012. ADME Studies of all Three Hexabromocyclododecane (HBCD) Diastereomers in Rats. International Workshop on Brominated Flame Retardants. 13th Workshop on Brominated and Other Flame Retardants, June 4-6, 2012, Winnipeg, MB, Canada.
Dioxins and other environmental contaminants in catfish from U.S. commerce - (Abstract Only)
Lupton, S.J., Huwe, J.K., Esteban, E., Miller, O. 2012. Dioxins and other environmental contaminants in catfish from U.S. commerce. Florida Pesticide Residue Workshop, July 15-18, 2012, St. Pete Beach, FL.
Absorption and distribution of perfluorooctane sulfonate (PFOS) in beef cattle - (Abstract Only)
Lupton, S.J., Huwe, J.K., Smith, D.J., Dearfield, K., Johnston, J.J. 2012. Absorption and distribution of perfluorooctane sulfonate (PFOS) in beef cattle. 244th American Chemical Society National Meeting, August 19-23, 2012, Philadelphia, PA. p. 91.
Absorption and excretion of 14C-perfluorooctanoic acid (PFOA) and perfluorooctane aulfonate (PFOS) in beef cattle - (Proceedings)
Lupton, S.J., Huwe, J.K., Smith, D.J., Dearfield, K., Johnston, J.J. 2011. Absorption and excretion of 14C-perfluorooctanoic acid (PFOA) and perfluorooctane aulfonate (PFOS) in beef cattle. Dioxin 2011. 31st International Symposium on Halogenated Persistent Organic Pollutants POPs’ Science in the Heart of Europe, August 21-25, 2011, Brussels, Belgium. Organohalogen Compounds. 73:1150-1153.
PCDD/Fs, PCBs, and PBDEs in catfish from U.S. Commerce - (Proceedings)
Huwe, J.K., Esteban, E., Miller, O. 2011. PCDD/Fs, PCBs, and PBDEs in catfish from U.S. commerce. Dioxin 2011. 31st International Symposium on Halogenated Persistent Organic Pollutants POPs' Science in the Heart of Europe. Organohalogen Compounds. 73:465-467.
Food Safety Categories:On-Farm Food Safety
Contaminants and Contamination
Methodology
Farm-to-Table Categories:On-farm food production
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