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Molecular Genetics, Genomics, and Phylogenetics of Foodborne Zoonotic Parasites Affecting Food Safety and Public Health
- Determine what genetic and genomic features distinguish Trichinella spiralis from Trichinella murrelli.
- Utilize genomics to determine if microsatellite loci can be used to trace zoonotic outbreaks of Trichinella spiralis.
- Determine the genetic features that account for the epidemic spread of certain strains of Toxoplasma gondii.
Secondly, develop the means to trace chains of transmission of Trichinella spp. Using markers which have already established the long-term dispersal history of T. spiralis (to the Americas in the pigs and rats brought by European colonists), researchers will attempt to discriminate instances of persistent on-farm transmission from sporadic introductions of T. spiralis to swine herds.
Finally, the genetics of T. gondii reproduction will be characterized. Both sexual and asexual reproduction can occur in T. gondii, and available data provide conflicting evidence as to the relative importance of each reproductive mode. These incongruous data leave in doubt whether this parasite evolves as an assemblage of distinct lineages, or whether it more closely resembles a coherent, interbreeding species. Additional data are needed to better resolve how T. gondii propagates and evolves. These results will help determine whether particular strains pose elevated food safety risk will help anticipate this parasite's evolutionary response to preventative interventions.
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