|Title:||Innovative Materials for Use in Mycotoxin Detection|
|Objective:||Toxins produced by fungi, mycotoxins, can cause devastating economic effects by affecting the safety and marketability of grain, and by causing disease in livestock. Diagnosis of health problems caused by mycotoxins is often difficult because while certain of the toxins can cause acute disease, most cause sub-acute or chronic effects that are more difficult to discern. |
For these reasons, attempts are made to detect mycotoxins at the many stages from crop production to finished product. As a result, a vital part of mycotoxin control is the availability of rapid, accurate, sensitive, and cost effective methods for toxin detection and quantitation. Fortunately, many such methods exist and are commercially available. With a few exceptions, most of these methods rely, in some fashion, on components that bind the toxins. Ideally, the binding components are highly specific for the toxins of interest and are capable of performing under their expected conditions of use. As analytical technologies progress, assays are required to perform under increasingly demanding conditions, requiring advances in their component materials.
We propose to apply the expertise of the investigators in synthetic chemistry, antibody development, immunoassay and sensor development, and instrumental assay methodology, toward the development of the next generation of toxin binding materials, such materials being the fundamental basis of improved analytical technologies for these toxins.
By improving technologies for detecting natural toxins, this project will have a direct impact on the ability of producers, processors, and regulatory agencies to improve monitoring programs for natural toxins, and thereby improve the safety of the U.S. food supply.
|More Info:||Monitoring and control of mycotoxins in commodities and foods is essential for reducing human and animal exposure to these toxins. Isolation and detection of toxins rely heavily upon toxin binding materials. As such, attaining this projectís objectives will allow the development of more rapid and sensitive methods that can be used for better control of mycotoxins at various stages in the supply chain through diversion of contaminated materials. Additionally, some of the binding materials from this work may have the potential to remove mycotoxins from contaminated products, thereby improving the safety and value of the commodity.|
|Funding Source:||United States Department of Agriculture (USDA), Agricultural Research Service (ARS)|
|Institutions:||USDA/ARS - Midwest Area|
|Pending USDA ARS Publications (NP 108):|
|Publications:||View related publications.|
|Food Safety Categories:||Government Policy and Regulations|
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