Food Safety Research Information Office
Title:Integrated Approach to the Detection and Control of Foodborne Parasites and the Impact on Food Safety
Objective:

Objective 1: Evaluate the impact of changing management and production practices (e.g. free range, confined, organic) on the incidence of Toxoplasmosis and Trichinella in swine, as it relates to foodborne risk.

Objective 2: Assess the effectiveness of on-farm interventions (such as passive immunization therapy as a feed supplement) to prevent enteric Toxoplasma infection in swine, consequent foodborne risk, and potential interaction with Salmonella foodborne infections in swine. C.1., PS 1B, and PS 1.D, Section 4.1.

Objective 3: Evaluate the impact of anthelminthic and antiprotozoal treatments on parasitic foodborne infections in swine and the potential foodborne risk. Evaluate the impact of anthelminthic and antiprotozoal treatments on the interaction between foodborne pathogen and foodborne parasitic infections, specficially coinfections of Toxoplasma, Trichinella with Salmonaella and Campylobacter in swine, and changes following treatments. C.1., P.S., 1.A, and P.S., 1.D.

More Info:
Approach: Toxoplasma gondii infects 11-20% of the U.S. population, causing birth defects in exposed pregnant women, devastating disease in immunocompromised individuals, and illness and loss of vision in otherwise healthy adults. Consumption of infected pork may be a significant source of infection for consumers in the U.S. Meat derived from pasture-raised pigs is of particular concern, since prevalence in these pigs may exceed 50%. Reducing the risk of foodborne human infection from meat requires adherence to livestock production practices that prevent exposure of animals to the parasite at the farm level, and the development of new treatments which can be used in pasture-raised pigs to prevent infection. Trichinella spiralis is a serious zoonotic pathogen with an unusually broad host and geographic range. Trichinella species infecting game animals pose a risk to humans consuming these meat products as well as a risk to domestic pigs that feed on their carcasses. Understanding the risk to pigs that have access to infected wildlife is an important component of on-farm certification efforts. In addition, the safety of meat from pasture-raised swine needs to be assessed in light of increasing consumer demand for organically-raised meat products. We will evaluate the impact of different management and production practices (e.g. free range, confinement, organically-raised pigs) on the incidence of Toxoplasma and Trichinella in swine, as it relates to foodborne risk, and assess the effectiveness of on-farm interventions (such as passive immunization therapy as a feed supplement) to prevent enteric Toxoplasma infection in swine, consequent foodborne risk, and potential interaction with Salmonella foodborne infections in swine.
Funding Source:United States Department of Agriculture (USDA), Agricultural Research Service (ARS)
Type:Appropriated
Start Date:2010
End Date:2015
Project Number:1245-32000-090-00
Accession Number:421090
Institutions:USDA/ARS - Beltsville Area Research Center
Investigators:Dubey, Jitender
Hill, Dolores
Urban, Joseph
Zarlenga, Dante
Project Reports:2013 Annual Report
2012 Annual Report
2011 Annual Report
Pending USDA ARS Publications (NP 108):
Published Journal
Articles USDA
ARS (NP 108):
Redescription of Sarcocystis fusiformis sarcocysts from the water buffalo (Bubalus bubalis)
Dubey J, Hilali M, Van Wilpeerna, Verma S, Calero-Bernal R, Adel-Wahab A.
Parasitology. 2014 Aug. [Epub ahead of print]
Identity of Sarcocystis species of the water buffalo (Bubalus bubalis) and cattle (Bos taurus) and the suppression of Sarcocystis sinensis as a nomen nudum
Dubey JP, Fayer R, Rosenthal BM, Calero-Bernal R, Uggla A.
Vet Parasitol. 2014 Jun 19. [Epub ahead of print]
Comments on "detection of Toxoplasma gondii in raw caprine, ovine, buffalo, bovine, and camel milk using cell cultivation, cat bioassay, capture ELISA, and PCR methods in Iran"
Dubey JP, Jones JL.
Foodborne Pathog Dis. 2014 Jun;11(6):500-1.
Toxoplasmosis-associated abortion in an alpaca (Vicugna pacos) fetus
Dubey JP, Johnson JE, Hanson MA, Pierce V.
J Zoo Wildl Med. 2014 Jun;45(2):461-4.
Toxoplasma gondii infection in llama (Llama glama): acute visceral disseminated lesions, diagnosis, and development of tissue cysts
Dubey JP, Newell TK, Verma SK, Calero-Bernal R, Stevens EL.
J Parasitol. 2014 Jun;100(3):288-94.
Diagnosis and treatment of Neospora caninum-associated dermatitis in a red fox (Vulpes vulpes) with concurrent Toxoplasma gondii infection
Dubey JP, Whitesell LE, Culp WE, Daye S.
J Zoo Wildl Med. 2014 Jun;45(2):454-7.
Effectiveness of a novel immunogenic nanoparticle platform for Toxoplasma peptide vaccine in HLA transgenic mice
El Bissati K, Zhou Y, Dasgupta D, Cobb D, Dubey JP, Burkhard P, Lanar DE, McLeod R.
Vaccine. 2014 May 30;32(26):3243-8.
Epidemiology of toxoplasmosis in white tailed deer (Odocoileus virginianus): occurrence, congenital transmission, correlates of infection, isolation, and genetic characterization of Toxoplasma gondii
Dubey JP, Dennis PM, Verma SK, Choudhary S, Ferreira LR, Oliveira S, Kwok OC, Butler E, Carstensen M, Su C.
Vet Parasitol. 2014 May 28;202(3-4):270-5.
Developmental Biology of Cystoisospora (Apicomplexa: Sarcocystidae monozoic tissue cysts)
Lindsay DS, Houk AE, Mitchell SM, Dubey JP.
J Parasitol. 2014 May 19. [Epub ahead of print]
Maternal and fetal immune response patterns in heifers experimentally infected with Neospora caninum in the second trimester of pregnancy - A descriptive study
Almería S, Serrano-Perez B, Darwich L, Araujo RN, Lopez-Gatius F, Dubey JP, Gasbarre LC.
Vet Parasitol. 2014 May 16. [Epub ahead of print]
Toxoplasma gondii merozoite gene expression analysis with comparison to the life cycle discloses a unique expression state during enteric development
Behnke MS, Zhang TP, Dubey JP, Sibley LD.
BMC Genomics. 2014 May 8;15:350.
Detection and genotyping of Toxoplasma gondii DNA in the blood and milk of naturally infected donkeys (Equus asinus)
Mancianti F, Nardoni S, Papini R, Mugnaini L, Martini M, Altomonte I, Salari F, D'Ascenzi C, Dubey JP.
Parasit Vectors. 2014 Apr 3;7:165.
Seroprevalence and correlates of Toxoplasma gondii infection in domestic pigs in Veracruz State, Mexico
Alvarado-Esquivel C, Romero-Salas D, García-Vázquez Z, Crivelli-Diaz M, Barrientos-Morales M, Lopez-de-Buen L, Dubey JP.
Trop Anim Health Prod. 2014 Apr;46(4):705-9.
Use of filter papers to determine seroprevalence of Toxoplasma gondii among hunted ungulates in remote Peruvian Amazon
Aston EJ, Mayor P, Bowman DD, Mohammed HO, Liotta JL, Kwok O, Dubey JP.
Int J Parasitol Parasites Wildl. 2014 Apr;3(1):15-19.
Geographical patterns of Toxoplasma gondii genetic diversity revealed by multilocus PCR-RFLP genotyping
Shwab EK, Zhu XQ, Majumdar D, Pena HF, Gennari SM, Dubey JP, Su C.
Parasitology. 2014 Apr;141(4):453-61.
Isolation of viable Neospora caninum from brains of wild gray wolves (Canis lupus)
Dubey JP, Jenkins MC, Ferreira LR, Choudhary S, Verma SK, Kwok OC, Fetterer R, Butler E, Carstensen M.
Vet Parasitol. 2014 Mar 17;201(1-2):150-3.
Seroprevalence of Toxoplasma gondii in donkeys (Equus asinus) in Italy
Machacova T, Bartova E, Di Loria A, Sedlak K, Mariani U, Fusco G, Fulgione D, Veneziano V, Dubey JP.
J Vet Med Sci. 2014 Mar 1;76(2):265-7.
Serologic evidence of Toxoplasma gondii infection in wild birds and mammals from southeast Brazil
Vitaliano SN, Soares HS, Pena HF, Dubey JP, Gennari SM.
J Zoo Wildl Med. 2014 Mar;45(1):197-9.
Epidemiological review of toxoplasmosis in humans and animals in Romania
Dubey JP, Hotea I, Olariu TR, Jones JL, Darabus G.
Parasitology. 2014 Mar;141(3):311-25.
Occurrence of Toxoplasma gondii antibodies in birds from the Atlantic Forest, state of São Paulo, Brazil
Gennari SM, Ogrzewalska M, Soares HS, Saraiva DG, Pinter A, Labruna MB, Dubey JP.
Vet Parasitol. 2014 Feb 24;200(1-2):193-7.
Genotyping Toxoplasma gondii from wildlife in Pennsylvania and identification of natural recombinants virulent to mice
Dubey JP, Van Why K, Verma SK, Choudhary S, Kwok OC, Khan A, Behinke MS, Sibley LD, Ferreira LR, Oliveira S, Weaver M, Stewart R, Su C.
Vet Parasitol. 2014 Feb 24;200(1-2):74-84.
Seropositivity of Toxoplasma gondii in domestic donkeys (Equus asinus) and isolation of T. gondii from farm cats
Dubey JP, Ness SL, Kwok OCH, Choudhary S, Mittel LD, Divers TJ.
Vet Parasitol. 2014 Jan 17;199(1-2):18-23.
Life cycle of Cystoisospora felis (Coccidia: Apicomplexa) in Cats and Mice
Dubey JP.
J Eukaryot Microbiol. 2014. [Epub ahead of print]
High prevalence of Toxoplasma gondii antibodies in dogs in Veracruz, Mexico
Alvarado-Esquivel C, Romero-Salas D, Garcia-Vazquez Z, Cruz-Romero A, Ibarra-Priego N, Ahuja-Aguirre C, Agular-Dominguez M, Perez De Leon A, Dubey J.
BMC Vet Res. 2014;10:191.
Experimental transmission of Sarcocystis muris (Apicomplexa: Sarcocystidae) sporocysts from a naturally infected cat (Felis catus) to immunocompetent and immunocompromised mice
Al-Kappany YM, Abu-Elwafa SA, Hilali M, Rosenthal BM, Dunams DB, Dubey JP.
J Parasitol. 2013 Dec;99(6):997-1001.
Isolation and RFLP genotyping of Toxoplasma gondii from the gray wolf (Canis lupus)
Dubey JP, Choudhary S, Ferreira LR, Kwok OC, Butler E, Carstensen M, Yu L, Su C.
Vet Parasitol. 2013 Nov 8;197(3-4):685-90.
Serotyping of Toxoplasma gondii in Cats (Felis domesticus) Reveals Predominance of Type II Infections in Germany
Maksimov P, Zerweck J, Dubey JP, Pantchev N, Frey CF, Maksimov A, Reimer U, Schutkowski M, Hosseininejad M, Ziller M, Conraths FJ, Schares G.
PLoS One. 2013 Nov 7;8(11):e80213.
Seroprevalence and correlates of Toxoplasma gondii infection in domestic sheep in Michoacán State, Mexico
Alvarado-Esquivel C, Silva-Aguilar D, Villena I, Dubey JP.
Prev Vet Med. 2013 Nov 1;112(3-4):433-7.
A new atypical genotype mouse virulent strain of Toxoplasma gondii isolated from the heart of a wild caught puma (Felis concolor) from Durango, Mexico
Dubey JP, Alvarado-Esquivel C, Herrera-Valenzuela V, Gayosso-Dominguez E, Oliveira S, Verma S, Choudhary S, Kwok OC, Su C .
Vet Parasitol. 2013 Nov;197(3):674-7.
Hepatic neosporosis in a dog treated for pemphigus foliaceus
Hoon-Hanks LL, Regan D, Dubey JP, Carol Porter M, Duncan CG.
J Vet Diagn Invest. 2013 Nov;25(6):807-10.
New pieces of the Trichinella puzzle
Pozio E, Zarlenga DS.
Int J Parasitol. 2013 Nov;43(12-13):983-97.
Pathogen exposure and blood chemistry in the Washington population of northern sea otters (Enhydra lutris kenyoni)
White L, Schuler K, Thomas N, Webb J, Saliki J, Ip H, Dubey JP, Frame E.
J Wildl Dis. 2013 Oct;49(4):887-99.
Pathogen exposure and blood chemistry in the Washington, USA population of northern sea otters (Enhydra lutris kenyoni)
White CL, Schuler KL, Thomas NJ, Webb JL, Saliki JT, Ip HS, Dubey JP, Frame ER.
J Wildl Dis. 2013 Oct;49(4):887-99.
Occurrence, isolation, and genetic characterization of Toxoplasma gondii from white-tailed deer (Odocoileus virginianus) in New Jersey
Dubey JP, Randall AR, Choudhary S, Ferreira LR, Verma SK, Oliveira S, Kwok OC, Su C.
J Parasitol. 2013 Oct;99(5):763-9.
Congenital transmission of Neospora caninum in white-tailed deer (Odocoileus virginianus)
Dubey JP, Jenkins MC, Kwok OC, Ferreira LR, Choudhary S, Verma SK, Villena I, Butler E, Carstensen M.
Vet Parasitol. 2013 Sep 23;196(3-4):519-22.
Fatal toxoplasmosis associated with an atypical Toxoplasma gondii strain in a Bennett's wallaby (Macropus rufogriseus) in Spain
Fernandez-Aguilar X, Ajzenberg D, Cabezon O, Martínez-Lopez A, Darwich L, Dubey JP, Almeria S.
Vet Parasitol. 2013 Sep 23;196(3-4):523-7.
Evidence for a structural role for acid-fast lipids in oocyst walls of Cryptosporidium, Toxoplasma, and Eimeria
Bushkin GG, Motari E, Carpentieri A, Dubey JP, Costello CE, Robbins PW, Samuelson J.
mbio. 2013 Sep 3;4(5):e00387-13.
Seroprevalence of Toxoplasma gondii infection in domestic rabbits in Durango State, Mexico
Alvarado-Esquivel C, Alvarado-Esquivel D, Villena I, Dubey JP.
Prev Vet Med. 2013 Sep 1;111(3-4):325-8.
Genetic diversity of Toxoplasma gondii isolates from Ethiopian feral cats
Dubey JP, Choudhary S, Tilahun G, Tiao N, Gebreyes WA, Zou X, Su C.
Vet Parasitol. 2013 Sep 1;196(1-2):206-8.
Isolation and characterization of new genetic types of Toxoplasma gondii and prevalence of Trichinella murrelli from black bear (Ursus americanus)
Dubey JP, Hill D, Zarlenga D, Choudhary S, Ferreira LR, Oliveira S, Verma SK, Kwok OC, Driscoll CP, Spiker H, Su C.
Vet Parasitol. 2013 Sep 1;196(1-2):24-30.
Seroprevalence of Toxoplasma gondii infection in captive mammals in three zoos in Mexico City, Mexico
Alvarado-Esquivel C, Gayosso-Dominguez EA, Villena I, Dubey JP.
J Zoo Wildl Med. 2013 Sep;44(3):803-6.
Prevalence of Toxoplasma gondii from free-range chickens (Gallus domesticus) from Addis Ababa, Ethiopia
Tilahun G, Tiao N, Ferreira LR, Choudhary S, Oliveira S, Verma SK, Kwok OC, Molla B, Saville WJ, Medhin G, Kassa T, Aleme H, Gebreyes WA, Su C, Dubey JP.
J Parasitol. 2013 Aug;99(4):740-1.
Molecular and biological characterization of first isolates of Hammondia hammondi from cats from Ethiopia
Dubey JP, Tilahun G, Boyle JP, Schares G, Verma SK, Ferreira LR, Oliveira S, Tiao N, Darrington C, Gebreyes WA.
J Parasitol. 2013 Aug;99(4):614-8.
Mechanics of the Toxoplasma gondii oocyst wall
Dumetre A1, Dubey JP, Ferguson DJ, Bongrand P, Azas N, Puech PH.
Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11535-40.
Isolation and genetic characterization of Toxoplasma gondii from mute swan (Cygnus olor) from the USA
Dubey JP, Choudhary S, Kwok OC, Ferreira LR, Oliveira S, Verma SK, Marks DR, Pedersen K, Mickley RM, Randall AR, Arsnoe D, Su C.
Vet Parasitol. 2013 Jul 1;195(1):42-6.
Prevalence of antibodies to Leishmania infantum and Toxoplasma gondii in horses from the north of Portugal
Lopes AP, Sousa S, Dubey J, Ribeiro AJ, Silvestre R, Cotovio M, Schallig HD, Cardoso L, Cordeiro-da-Silva A.
Parasit Vector. 2013 Jun 17;6:178.
Seroprevalence of Toxoplasma gondii infection in dairy goats in Michoacán State, Mexico
Alvarado-Esquivel C, Silva-Aguilar D, Villena I, Dubey JP.
J Parasitol. 2013 Jun;99(3):540-2.
Development of early tissue cysts and associated pathology of Besnoitia besnoiti in a naturally infected bull (Bos taurus) from South Africa
Dubey JP, van Wilpe E, Blignaut DJ, Schares G, Williams JH.
J Parasitol. 2013 Jun;99(3):459-66.
Serological evidence of Toxoplasma gondii infection in five species of bats in China
Yuan ZG, Luo SJ, Dubey JP, Zhou DH, Zhu YP, He Y, He XH, Zhang XX, Zhu XQ.
Vector Borne Zoonotic Dis. 2013 Jun;13(6):422-4.
TsDAF-21/Hsp90 is expressed in all examined stages of Trichinella spiralis
Yang Y, Qin W, Zarlenga D, Cao L, Tian G.
Vet Parasitol. 2013 May 20;194(2-4):171-4.
An investigation into the seroprevalence of Toxoplasma gondii, Bartonella spp., feline immunodeficiency virus (FIV), and feline leukaemia virus (FeLV) in cats in Addis Ababa, Ethiopia
Tiao N, Darrington CL, Molla B, Saville WA, Tilahun G, Kwok OC, Gebreyes WA, Lappin MR, Jones JL, Dubey JP.
Epidemiol Infect. 2013 May;141(5):1029-33.
Hammondia hammondi, an avirulent relative of Toxoplasma gondii, has functional orthologs of known T. gondii virulence genes
Walzer KA, Adomako-Ankomah Y, Dam RA, Herrmann DC, Schares G, Dubey JP, Boyle JP.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7446-51.
Evidence of tRNA cleavage in apicomplexan parasites: Half-tRNAs as new potential regulatory molecules of Toxoplasma gondii and Plasmodium berghei
Galizi R, Spano F, Giubilei MA, Capuccini B, Magini A, Urbanelli L, Ogawa T, Dubey JP, Spaccapelo R, Emiliani C, Di Cristina M.
Mol Biochem Parasitol. 2013 Apr;188(2):99-108.
Genetic characterization of viable Toxoplasma gondii isolates from stray dogs from Giza, Egypt
El Behairy AM, Choudhary S, Ferreira LR, Kwok OC, Hilali M, Su C, Dubey JP.
Vet Parasitol. 2013 Mar 31;193(1-3):25-9.
Global proteomic analysis of the oocyst/sporozoite of Toxoplasma gondii reveals commitment to a host-independent lifestyle
Possenti A, Fratini F, Fantozzi L, Pozio E, Dubey JP, Ponzi M, Pizzi E, Spano F.
BMC Genomics. 2013 Mar 15;14:183.
Toxoplasma gondii abortion storm in sheep on a Texas farm and isolation of mouse virulent atypical genotype T. gondii from an aborted lamb from a chronically infected ewe
Edwards JF, Dubey JP.
Vet Parasitol. 2013 Feb 18;192(1-3):129-36.
Novel tools for the diagnosis and differentiation of acute and chronic bovine besnoitiosis
Schares G, Langenmayer MC, Scharr JC, Minke L, Maksimov P, Maksimov A, Schares S, Bärwald A, Basso W, Dubey JP, Conraths FJ, Gollnick NS.
Int J Parasitol. 2013 Feb;43(2):143-54.
Ante-mortem diagnosis, diarrhea, oocyst shedding, treatment, isolation, and genetic typing of Toxoplasma gondii associated with clinical toxoplasmosis in a naturally infected cat
Dubey JP, Prowell M.
J Parasitol. 2013 Feb;99(1):158-60.
Toxoplasma gondii prevalence in farm animals in the United States
Hill DE, Dubey JP.
Int J Parasitol. 2013 Feb;43(2):107-13.
Serological survey of dogs from Egypt for antibodies to Leishmania species
Rosypal AC, Bowman SS, Epps SA, El Behairy AM, Hilali M, Dubey JP.
J Parasitol. 2013 Feb;99(1):170-1.
Seroprevalence of Toxoplasma gondii in domestic sheep in Oaxaca State, Mexico
Alvarado-Esquivel C, Estrada-Malacon MA, Reyes-Hernandez SO, Perez-Ramirez JA, Trujillo-Lopez JI, Villena I, Dubey JP.
J Parasitol. 2013 Feb;99(1):151-2.
Isolation of viable Toxoplasma gondii from tissues and feces of cats from Addis Ababa, Ethiopia
Dubey JP, Darrington C, Tiao N, Ferreira LR, Choudhary S, Molla B, Saville WJ, Tilahun G, Kwok OC, Gebreyes WA.
J Parasitol. 2013 Feb;99(1):56-8.
Spatiotemporal dynamics of Toxoplasma gondii infection in Canadian lynx (Lynx canadensis) in western Québec, Canada
Simon A, Bigras Poulin M, Rousseau AN, Dubey JP, Ogden NH.
J Wildl Dis. 2013 Jan;49(1):39-48.
Experimental transmission of Sarcocystis muris (Apicomplexa): Sarcocystidae from the feces of a naturally infected feral cat (Felis catus) to immunocompetent and immunocompromised mice
Kappany A, Abu-Elwafa S, Hilali M, Rosenthal B, Dunams D, Dubey JP.
J Parasitol. 2013;99(6):997-1001.
Seroprevalence of Toxoplasma gondii in wild marsupials and rodents from the Atlantic Forest of Pernambuco State, northeastern region, Brazil
Siqueira DB, Alessio FM, Mauffrey JF, Marvulo MFV, Ribeiro VO, Oliveira RL, Pena HFJ, Gennari SM, Mota RA, Faustino MAG, Alves LC, Dubey JP, Silva JCR.
J Parasitol. 2013;99(6):1140-3.
Neosporosis in dogs
Dubey JP.
CABI. 2013;:.
Prevalence of antibodies to Sarcocystis neurona and Neospora hughesi in horses from Mexico
Yeargan MR, Alvarado-Esquivel C, Dubey JP, Howe DK.
Parasite. 2013;20:29.
Isolation and RFLP genotyping of Toxoplasma gondii from the mongoose (Herpestes auropunctatus) in Grenada, West Indies
Choudhary S, Zieger U, Sharma RN, Chikweto A, Tiwari KP, Ferreira LR, Oliveira S, Barkley LJ, Verma SK, Kwok OCH, Su C, Dubey JP.
J Zoo Wildl Med. 2013;44(4):1127-30.
Identification of Sarcocystis capracanis in cerebrospinal fluid from sheep with neurological disease
Formisano P, Aldridge B, Alony Y, Beekhuis L, Davies E, Del Pozo J, Dunn K, English K, Morrison L, Sargison N, Seguino A, Summers BA, Wilson D, Milne E, Beard PM.
Vet Parasitol. 2013;193(1-3):252-5.
High prevalence of Toxoplasma gondii antibodies in domestic pigs in Oaxaca State, Mexico
Alvarado-Esquivel C, Estrada-Malacon MA, Reyes-Hernandez SO, Perez-Ramirez JA, Trujillo-Lopez JI, Villena I, Dubey JP.
J Parasitol. 2012 Dec;98(6):1248-50.
Serological evidence of Besnoitia spp. infection in Canadian wild ruminants and strong cross-reaction between Besnoitia besnoiti and Besnoitia tarandi
Gutierrez-Expósito D1, Ortega-Mora LM, Gajadhar AA, Garcia-Lunar P, Dubey JP, Alvarez-Garcia G.
Vet Parasitol. 2012 Nov 23;190(1-2):19-28.
Disseminated toxoplasmosis in Antillean manatees Trichechus manatus manatus from Puerto Rico
Bossart GD, Mignucci-Giannoni AA, Rivera-Guzman AL, Jimenez-Marrero NM, Camus AC, Bonde RK, Dubey JP, Reif JS.
Dis Aquat Organ. 2012 Nov 8;101(2):139-44.
Salicylanilide inhibitors of Toxoplasma gondii
Fomovska A, Wood RD, Mui E, Dubey JP, Ferreira LR, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Welsh WJ, Sommerville C, Woods S, Roberts C, McLeod R.
J Med Chem. 2012 Oct 11;55(19):8375-91.
Seroprevalence of Toxoplasma gondii infection in domestic horses in Durango State, Mexico
Alvarado-Esquivel C, Rodríguez-Pena S, Villena I, Dubey JP.
J Parasitol. 2012 Oct;98(5):944-5.
B-1,3-glucan, which can be targeted by drugs, forms a trabecular scaffold in the oocyst walls of Toxoplasma and Eimeria
Bushkin GG, Motari E, Magnelli P, Gubbels MJ, Dubey JP, Miska KB, Bullitt E, Costello CE, Robbins PW, Samuelson J.
mbio. 2012 Sep 25;3(5):e00258-12.
What is your diagnosis? Duodenal brush preparation from a dog
Palic J, Parker VJ, Fales-Williams AJ, Jarvinen JA, Dubey JP.
Vet Clin Path. 2012 Sep;41(3):431-2.
High seroprevalence of Toxoplasma gondii and Neospora caninum in the Common raven (Corvus corax) in the Northeast of Spain
Molina-Lopez R, Cabezon O, Pabon M, Darwich L, Obon E, Lopez-Gatius F, Dubey JP, Almeria S.
Res Vet Sci. 2012 Aug;93(1):300-2.
Seroepidemiology of Toxoplasma gondii infection in women from the North of Portugal in their childbearing years
Lopes AP, Dubey JP, Moutinho O, Gargate MJ, Vilares A, Rodrigues M, Cardoso L.
Epidemiol Infect. 2012 May;140(5):872-7.
Seroprevalence of Toxoplasma gondii infection in domestic sheep in Durango State, Mexico
Alvarado-Esquivel C, García-Machado C, Alvarado-Esquivel D, Vitela-Corrales J, Villena I, Dubey JP.
J Parasitol. 2012 Apr;98(2):271-3.
Serological evidence of Toxoplasma gondii infection in captive marine mammals in Mexico
Alvarado-Esquivel C, Sánchez-Okrucky R, Dubey JP.
Vet Parasitol. 2012 Mar 23;184(2-4):321-4.
Molecular genotyping of Toxoplasma gondii from Central and South America revealed high diversity within and between populations
Rajendran C, Su C, Dubey JP.
Infect Genet Evol. 2012 Mar;12(2):359-68.
Prevalence of Toxoplasma gondii and Neospora caninum antibodies in Spanish ibex (Capra pyrenaica hispanica)
Garcia-Bocanegra I, Cabezon O, Pabon M, Gomez-Guillamon F, Arenas A, Alcaide E, Salas-Vega R, Dubey JP, Almeria S.
Vet J. 2012 Feb;191(2):257-60.
Oral oocyst-induced mouse model of toxoplasmosis: effect of infection with Toxoplasma gondii strains of different genotypes, dose, and mouse strains (transgenic, out-bred, in-bred) on pathogenesis and mortality
Dubey JP, Ferreira LR, Martins J, McLeod R.
Parasitology. 2012 Jan;139(1):1-13.
Seroprevalence of Toxoplasma gondii in free-living Amazon River dolphins (Inia geoffrensis) from central Amazon, Brazil
Santos PS, Albuquerque GR, da Silva VM, Martin AR, Marvulo MF, Souza SL, Ragozo AM, Nascimento CC, Gennari SM, Dubey JP, Silva JC.
Vet Parasitol. 2011 Dec 29;183(1-2):171-3.
Seroprevalence of Toxoplasma gondii infection in domestic goats in Durango State, Mexico
Alvarado-Esquivel C, García-Machado C, Vitela-Corrales J, Villena I, Dubey JP.
Vet Parasitol. 2011 Dec 29;183(1-2):43-6.
Sarcocystis neurona retinochoroiditis in a sea otter (Enhydra lutris kenyoni)
Dubey JP, Thomas NJ.
Vet Parasitol. 2011 Dec 29;183(1-2):156-9.
Seroprevalence of Neospora caninum in free-range chickens (Gallus domesticus) from the Americas
Martins J, Kwok OC, Dubey JP.
Vet Parasitol. 2011 Dec 15;182(2-4):349-51.
Serological survey and risk factors for Toxoplasma gondii in domestic ducks and geese in Lower Saxony, Germany
Maksimov P, Buschtöns S, Herrmann DC, Conraths FJ, Görlich K, Tenter AM, Dubey JP, Nagel-Kohl U, Thoms B, Bötcher L, Kühne M, Schares G.
Vet Parasitol. 2011 Dec 15;182(2-4):140-9.
Toxoplasma gondii: the changing paradigm of congenital toxoplasmosis
Lindsay DS, Dubey JP.
Parasitology. 2011 Dec;138(14):1829-31.
Unrecognized ingestion of Toxoplasma gondii oocysts leads to congenital toxoplasmosis and causes epidemics in North America
Boyer K, Hill D, Mui E, Wroblewski K, Karrison T, Dubey JP, Sautter M, Noble AG, Withers S, Swisher C, Heydemann P, Hosten T, Babiarz J, Lee D, Meier P, McLeod R; Toxoplasmosis Study Group.
Clin Infect Dis. 2011 Dec;53(11):1081-9.
Seroprevalence of Toxoplasma gondii in pigs, sheep, goats, and cattle from Grenada and Carriacou, West Indies
Chikweto A, Kumthekar S, Tiwari K, Nyack B, Deokar MS, Stratton G, Macpherson CN, Sharma RN, Dubey JP.
J Parasitol. 2011 Oct;97(5):950-1.
Gray wolf (Canis lupus) is a natural definitive host for Neospora caninum
Dubey JP, Jenkins MC, Rajendran C, Miska K, Ferreira LR, Martins J, Kwok OC, Choudhary S.
Vet Parasitol. 2011 Sep 27;181(2-4):382-7.
Cytokine gene expression at the materno-foetal interface after experimental Neospora caninum infection of heifers at 110 days of gestation
Almeria S, Araujo RN, Darwich L, Dubey JP, Gasbarre LC.
Parasite Immunol. 2011 Sep;33(9):517-23.
High prevalence and genotypes of Toxoplasma gondii isolated from goats, from a retail meat store, destined for human consumption in the USA
Dubey JP, Rajendran C, Ferreira LR, Martins J, Kwok OC, Hill DE, Villena I, Zhou H, Su C, Jones JL.
Int J Parasitol. 2011 Jul;41(8):827-33.
Non-Journal Publications:
The history and life cycle of Toxoplasma gondii - (Book / Chapter)
Dubey, J.P. 2013. The history and life cycle of Toxoplasma gondii. In: Weiss, L.M. and Kim, K., editors. Toxoplasma gondii, The model apicomplexan: Perspective and methods. 2nd edition. Waltham, MA: Elsevier. p. 1-14.
Toxoplasmosis in wild and domestic animals - (Book / Chapter)
Lindsay, D.S., Dubey, J.P. 2013. Toxoplasmosis in wild and domestic animals. In: Weiss, L., Kim, K., editors. New York, NY: Elsevier. p. 193-215.
Toxoplasma gondii - (Book / Chapter)
Guy, E., Hill, D.E., Dubey, J.P. 2012. Toxoplasma gondii. In: Robertson, L.J., Smith, H.V., editors. Food Borne Protozoan Parasites. Hauppauge, NY: Nova Publishers. p. 167-188.
Toxoplasmosis and Neosporosis - (Book / Chapter)
Dubey, J.P., Lappin, M.R. 2012. Toxoplasmosis and Neosporosis. In: Infectious Diseases of Dogs and Cats. Philadelphia: Elsevier. p. 806-827.
Enteric coccidiosis - (Book / Chapter)
Dubey, J.P., Greene, C. 2012. Enteric coccidiosis. In: Infectious Diseases of Dogs and Cats. Philadelphia: Elsevier. p. 828-839.
Neosporosis in animals-the last five years - (Literature Review)
Dubey, J.P., Schares, G. 2011. Neosporosis in animals-the last five years. Veterinary Parasitology. 180:90-108.
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